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Because GLS normally varies with age, sex, and LV loading conditions, defining abnormal GLS is not straightforward. However, in adults, GLS 16% (sic) is abnormal, GLS >18% (sic) is normal, and GLS 16% to 18% is borderline. (Editor’s note: GLS is expressed as a negative number.)Thus far, preliminary data suggest that LV GLS may be superior to LVEF and WMSI for the prediction of long-term outcome in different populations. 14 However, whether LV GLS is related to long-term outcome in patients with chronic ischemic heart disease is not established yet.
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