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According to LaPlace’s Law, the load on any region of the myocardium is given as follows: (pressure×radius)/ (2×wall thickness); thus, an increase in pressure can be offset by an increase in wall thickness.Myocardial relaxation and left ventricular diastolic function. Diastolic function is determined by the efficiency of myocardial relaxation. The degree and velocity of relaxation are the key parameters. Ideally, relaxation should proceed rapidly and the ventricle should expand substantially.
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